Allergy Immunotherapy in Singapore

Allergy immunotherapy, or desensitisation, is a long-term treatment that reduces sensitivity to allergens, alleviating symptoms affecting the nose, sinuses, throat, and airways.

Unlike medications that only manage symptoms, immunotherapy modifies the immune system’s response, providing lasting relief. It is particularly beneficial for persistent nasal congestion, sinus inflammation, and allergic airway conditions affecting the ear, nose, and throat.

doctor img
Dr Gan Eng Cern

MBBS

MRCS (Edin)

mmed (orl)

FAMS

Allergy Immunotherapy in Singapore Allergy Immunotherapy in Singapore

ENT Conditions Treated with Allergy Immunotherapy

Allergy immunotherapy helps manage persistent nasal, sinus, and airway inflammation caused by allergens. Conditions include:

Allergic Rhinitis (Hay Fever)

Causes sneezing, congestion, runny nose, and postnasal drip due to pollen, dust mites, mould, and pet dander. If untreated, it can lead to sinus infections, nasal polyps, and ear blockages. Immunotherapy reduces inflammation, providing long-term relief.

Chronic Sinusitis with Allergic Triggers

Allergies can worsen sinus infections, causing facial pain, congestion, and thick mucus. Immunotherapy reduces inflammation, improving sinus drainage and lowering infection risk.

Eustachian Tube Dysfunction

Allergies can block the Eustachian tube, leading to ear fullness, muffled hearing, and fluid buildup. Immunotherapy reduces nasal and ear inflammation, improving ear function.

Allergic Conjunctivitis

Often linked to rhinitis, causing red, itchy, and watery eyes from pollen, dust, and pet dander. Immunotherapy helps reduce sensitivity and flare-ups.

Nasal Polyps

Chronic allergies can cause nasal polyps, leading to nasal obstruction, loss of smell, and sinus infections. Immunotherapy helps reduce inflammation and may prevent recurrence.

Asthma with Allergic Triggers

Nasal and sinus allergies can worsen asthma, making breathing more difficult. Immunotherapy helps reduce airway inflammation and improve asthma control.

Benefits of Allergy Immunotherapy

For patients with persistent nasal, sinus, and throat allergies, immunotherapy provides long-term relief by addressing the root cause of allergic reactions.

  • Lasting Symptom Relief: Helps the immune system develop tolerance to allergens, leading to fewer allergic reactions and sustained improvement even after treatment completion.
  • Less Reliance on Medications: Reduces the need for antihistamines, nasal sprays, decongestants, and steroids, minimising side effects and long-term dependency.
  • Prevention of Complications: Lowers the risk of chronic sinus infections, nasal polyps, and allergic asthma by reducing allergic inflammation.
  • Improved Breathing & Sleep Quality: Relieves nasal congestion and airway obstruction, promoting better breathing, restful sleep, and reduced daytime fatigue.
  • Long-Term Allergy Control: Helps modify the immune system’s response, making seasonal and environmental allergies less severe over time.

Methods of Allergy Immunotherapy

Allergy immunotherapy works by gradually exposing the immune system to allergens, reducing sensitivity over time. It can be administered in two primary ways:

Sublingual Immunotherapy (SLIT) – Allergy Drops/Tablets

SLIT involves placing allergen extracts under the tongue in tablet or liquid drop form. It is a self-administered daily treatment taken at home after an initial supervised dose. It is primarily used for grass pollen, dust mites, and ragweed allergies.

Both methods help reduce allergic reactions and prevent symptoms from worsening over time. The choice between SCIT and SLIT depends on the specific allergen, patient preference, and treatment goals.

Dr. Gan Eng Cern consulting with patient Dr. Gan Eng Cern consulting with patient

Preparing for Allergy Immunotherapy

Before starting immunotherapy, a thorough evaluation at a clinic and planning process is required to ensure the treatment is appropriate and tailored to individual needs. Preparation includes:

  • Allergy Testing: Skin prick or blood tests identify specific allergens triggering symptoms. This helps determine the exact formulation for immunotherapy.
  • Medical History Review: An ENT doctor will assess existing conditions, medications, and previous allergy treatments to ensure immunotherapy is safe and beneficial.
  • Managing Existing Symptoms: Antihistamines, nasal sprays, or other allergy medications may be recommended before and during early treatment phases to help manage symptoms while immunotherapy takes effect.

Allergy Immunotherapy Procedure

Initial Assessment

A thorough evaluation is conducted to determine if immunotherapy is suitable. This includes allergy testing (skin prick or blood tests) to identify specific allergens and a medical history review to assess any existing conditions or medications that may affect treatment. Based on these findings, a personalised treatment plan is developed.

Build-up Phase

This phase gradually increases allergen exposure to help the immune system adapt.

For Subcutaneous Immunotherapy (SCIT – Allergy Shots): Small doses of the allergen are injected under the skin once or twice a week, with the concentration increasing over time. This phase typically lasts 3–6 months. After each injection, patients remain in the clinic for 30 minutes to monitor for any reactions.

For Sublingual Immunotherapy (SLIT – Allergy Drops/Tablets): The first dose is administered in a clinic under supervision. After that, patients continue daily self-administration at home.

Both methods help reduce allergic reactions and prevent symptoms from worsening over time. The choice between SCIT and SLIT depends on the specific allergen, patient preference, and treatment goals.

Maintenance Phase

Once the optimal dose is reached, the frequency of treatment is reduced to maintain long-term immune tolerance.

  • For SCIT: Injections are given once a month and continue for 3–5 years.
  • For SLIT: Daily doses continue at home for a similar duration.

This phase helps reinforce allergen tolerance and gradually reduces symptoms.

Monitoring and Adjustments

Regular follow-ups are conducted to track progress, adjust doses, and manage any side effects. Over time, symptoms decrease, and many patients experience lasting relief even after stopping treatment.

Are Your Symptoms Affecting Your Quality of Life?

Consult our MOH-accredited specialist for an accurate diagnosis & personalised treatment plan today.

human head showing sinus structure

Post-Treatment Care

After completing allergy immunotherapy, patients should follow these steps to maintain results and prevent symptom recurrence.

  • Continue Allergen Avoidance: Although immunotherapy reduces sensitivity, limiting exposure to allergens such as dust mites, pollen, pet dander, and mould can further prevent flare-ups. Using air purifiers, regular cleaning, and avoiding known triggers can help.
  • Monitor Symptoms: Patients should track their allergy symptoms and note any recurring or worsening reactions. While many experience lasting relief, some may need additional management or a follow-up course of immunotherapy.
  • Use Medication If Needed: Even after immunotherapy, occasional use of antihistamines, nasal sprays, or other allergy medications may be required for mild symptoms, especially during peak allergy seasons.
  • Schedule Follow-Up Appointments: Regular check-ups with a doctor can help assess long-term treatment success and determine if any further intervention is needed.

Potential Side Effects

Allergy immunotherapy is generally safe, but mild side effects can occur. Local reactions include redness, swelling, or itching at the injection site (SCIT) or in the mouth (SLIT). Some may experience sneezing, congestion, hives, or mild wheezing. Rarely, anaphylaxis can cause breathing difficulties, throat swelling, or dizziness, requiring immediate care. To reduce risk, SCIT is given in a medical setting with monitoring, while SLIT requires an initial supervised dose. Most side effects are mild and temporary, with dose adjustments as needed.

For Singaporeans & Singapore Permanent Residents

Medisave & Insurance Shield Plan approved

Your ENT procedure may be eligible for Medisave claims, with the claimable amount varying based on the procedure’s complexity. For additional options, including the use of your insurance or Integrated Shield Plan, reach out to our friendly clinic staff today for assistance.

Frequently Asked Questions (FAQ)

How long does it take to notice improvements with allergy immunotherapy?

Most patients begin to notice symptom improvement within a few months of starting treatment. However, significant and lasting relief typically occurs after 12 to 18 months, with the full benefits developing over the course of 3 to 5 years.

What happens if I miss a dose or appointment?

If a dose is missed, your doctor may need to adjust your next dose to avoid potential side effects. For SCIT (allergy shots), missing multiple doses may require restarting at a lower dose. For SLIT (sublingual tablets), missing a few days typically does not require restarting, but consistency is recommended for best results.

Can I stop treatment early if my symptoms improve?

Stopping treatment too soon may lead to symptom relapse. For long-term benefits, it is recommended to complete the full 3–5 year course. However, some patients with early improvement may switch to a shorter maintenance schedule based on their doctor’s advice.

Dr. Gan picture

Dr Gan Eng Cern

MBBS

MRCS (Edin)

mmed (orl)

FAMS

With over 15 years of experience, Dr Gan specialises in the comprehensive management of a broad range of conditions related to the ear, nose and throat (ENT), and head and neck.

Dr. Gan has contributed to the academic field as a Senior Clinical Lecturer at the Yong Loo Lin School of Medicine, National University of Singapore. He is recognised for his extensive research work, with numerous contributions to reputable international ENT journals. Dr Gan is also highly sought after as a speaker and has shared his surgical knowledge as a surgical dissection teacher at various prominent ENT conferences and courses.

  • 2020 – Reader’s Choice Gold Award for Best ENT Specialist (Expat Living Singapore)
  • 2016 – Best Educator Award (Eastern Health Alliance)
  • 2016 – “Wow” Award (Patient Compliment)
  • 2014 – Eastern Health Alliance Caring Award – Silver
  • 2014 – 19th Yahya Cohen Memorial Lectureship (awarded by the College of Surgeons, Academy of Medicine Singapore for best scientific surgical paper)
  • 2012 – Human Manpower Development Award (Ministry of Health, Singapore)
  • 2007 – Singhealth Best Doctor Award

Qualifications

  • MBBS – Bachelor of Science, Bachelor of Medicine, Bachelor of Surgery (University of New South Wales, Sydney, Australia)
  • MRCS (Edin) – Member of the Royal College of Surgeons Edinburgh, United Kingdom
  • MMed (ORL) – Master of Medicine in ENT (National University of Singapore)
  • FAMS – Fellow of the Academy of Medicine Singapore
Dr Gan performing sinus procedure

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    A Specialist Clinic for Sinus, Snoring & ENT

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    Mount Elizabeth Novena Hospital
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